Guanine pairs with which base?

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Study for the DNA Biology Test. Dive into key concepts with multiple choice questions, flashcards, and detailed explanations. Enhance your understanding and prepare confidently for your exam!

Multiple Choice

Guanine pairs with which base?

Explanation:
Base pairing in DNA relies on specific hydrogen bonding and size fit between bases. Guanine is a purine, so it pairs with a pyrimidine to keep the DNA double helix uniformly wide; the only partner that fits and forms stable hydrogen bonds with guanine is cytosine. In DNA, this G–C pairing involves three hydrogen bonds, which adds extra stability compared to adenine–thymine pairs. Uracil is used in RNA and pairs with adenine there, not guanine. So cytosine is the base that pairs with guanine.

Base pairing in DNA relies on specific hydrogen bonding and size fit between bases. Guanine is a purine, so it pairs with a pyrimidine to keep the DNA double helix uniformly wide; the only partner that fits and forms stable hydrogen bonds with guanine is cytosine. In DNA, this G–C pairing involves three hydrogen bonds, which adds extra stability compared to adenine–thymine pairs. Uracil is used in RNA and pairs with adenine there, not guanine. So cytosine is the base that pairs with guanine.

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