Eukaryotic transcription factors include activators and coactivators.

Eukaryotic transcription factors include activators and coactivators.

• A. False
• B. Not applicable
• C. True
• D. Sometimes

Answer: (C)

In eukaryotic gene regulation, transcription factors include proteins that bind DNA to increase transcription (activators) and proteins that don’t bind DNA themselves but help activators and the transcription machinery work more efficiently (coactivators). Activators attach to specific DNA sequences such as enhancers to recruit or stabilize the assembly of RNA polymerase II and other factors at the promoter, boosting transcription. Coactivators, on the other hand, interact with DNA-bound activators or with components of the transcription machinery and often modify chromatin or serve as bridges to RNA polymerase II, enhancing transcription without directly contacting the DNA. Because both activators and coactivators play roles in upregulating transcription in eukaryotes, this statement is true.

In eukaryotic gene regulation, transcription factors include proteins that bind DNA to increase transcription (activators) and proteins that don’t bind DNA themselves but help activators and the transcription machinery work more efficiently (coactivators). Activators attach to specific DNA sequences such as enhancers to recruit or stabilize the assembly of RNA polymerase II and other factors at the promoter, boosting transcription. Coactivators, on the other hand, interact with DNA-bound activators or with components of the transcription machinery and often modify chromatin or serve as bridges to RNA polymerase II, enhancing transcription without directly contacting the DNA. Because both activators and coactivators play roles in upregulating transcription in eukaryotes, this statement is true.